• larussoDr. Melissa LaRusso, Rheumatologist at Regional Orthopedics, was born and raised in Queens, New York. She earned a B.S. in Pharmacology from St. John’s University where she graduated Magna Cum Laude.

    After working as a registered pharmacist in both hospital and retail pharmacies, Dr. LaRusso chose to pursue her childhood dream of becoming a physician. She continued to work as a pharmacist throughout medical school and graduated from New York College of Osteopathic Medicine, Old Westbury in 2007 with a Doctor of Osteopathic Medicine degree.

    Dr. LaRusso completed her residency in Internal Medicine at Beth Israel Medical Center in NYC. Following her residency, Dr. La Russo focused on Rheumatology, a specialty that allowed her to apply her background in pharmacology to the treatment of autoimmune conditions. She completed her Rheumatology fellowship at North Shore-LIJ Health System in Manhasset, NY. In addition she conducted research at the Feinstein Institute for Medical Research and performed studies focusing on the treatment of Systemic lupus erythematosus (SLE).

    Following graduation in 2012, Dr. LaRusso accepted a faculty position at Mount Sinai/St. Luke’s Roosevelt Hospitals in NYC where she treated complex autoimmune conditions in the inpatient hospital setting. As both a faculty and teaching staff member, Dr. LaRusso was extensively involved in resident physician education, teaching both clinical and pharmacologic medicine. A board certified physician trained in rheumatology, Dr. LaRusso is qualified to treat all rheumatologic conditions, all forms of arthritis, other autoimmune and inflammatory disorders as well as osteoporosis. She also has specialized interests in Lupus, Rheumatoid Arthritis, Psoriatic Arthritis, Sjgoren’s Syndrome, Gout, and Fibromyalgia. Dr. LaRusso is also one of only a few physicians in Staten Island who prescribes medical marijuana as a treatment for her patients.

    Dr. Melissa Russo sees patients in Staten Island, NY and Manhattan, NY.


    • North Shore-LIJ Health System, Manhasset, NY, Rheumatology Fellowship
    • Beth Israel Medical Center, New York, NY, Internal Medicine Residency
    • New York College of Osteopathic Medicine, Old Westbury, NY, D.O.
    • St. John’s University, Queens, NY, B.S. in Pharmacology (Magna Cum Laude)

    Pharmacologic Therapy

    • DMARDS-methotrexate, Azathioprine, Leflunomide, Sulfasalazine, Hydroxychloroquine
    • PDE4 inhibitors-Otezla
    • Biologic response modifiers (TNF inhibitors (Humira, Enbrel, Cimzia, Simponi), Monoclonal antibody to CD20 (Rituxan), Costimulatory blocker (Orencia), JAK inhibitor (Xeljanz), Monoclonal antibody to IL-6 (Actemra), IL-1 inhibitor (Kineret), Monoclonal antibody to IL-12 & il-23 (Stelara), Monoclonal antibody to blys (Benlysta)
    • Alkylating agents-cyclophosphamide
    • Analgesics
    • NSAIDS
    • Xanthine oxidase inhibitors-allopurinol,Uloric
    • Glucocorticoids- intra-articular / systemic
    • Bisphosphonates-Actonel,Boniva,Fosamax
    • Rankl inhibitors-Prolia
    • Recombinant pth-Forteo
    • Cholongeric receptor agonist-Evoxac, Pilocarpine
    • Steroids

    On Site Diagnostics/Services

    • Digital Radiology/ XRay
    • MRI
    • Diagnostic Ultrasound
    • Nerve Conduction Studies
    • Electromyography
    • Physical Therapy/Rehabilitation


    Patient Reviews

    vitals-sprite2Anonymous Mar 18th, 2016

    Dr Larusso is very good, efficient, informative. I received knee injections from the doctor. She truly has smooth hands I did not feel a thing.

    vitals-sprite2Kathy Mar 10th, 2016

    Explains everything prior to the treatment

    vitals-sprite2Anonymous Feb 19th, 2016

    Dr. Larusso is the best rheumatologist I have come across. I have been to at least 3 others and they do not compare to Dr. Larusso. Her adorable persona and positive energy made me feel very comfortable throughout my entire experience in the office. Hats off to the best rheumatologist I have ever met !!!!!

    vitals-sprite2John Feb 17th, 2016

    Knowledgeable and great bedside manner. Put me at ease and formed a plan for moving forward to disagnose and treat. Highly recommend!

    vitals-sprite2Anonymous Feb 8th, 2016

    Larusso .. Dr Larusso was extremely thorough and knowledgeable and made us understand exactly what might be going on .. Very friendly and very professional .. Great staff

    vitals-sprite2Vito R. Jan 26th, 2016

    I have been to several doctors already about my knee pain and though this was going to be more of the same but I was surprised that Dr LARUSSO took the time to actually show me what was causing my pain by using a medical knee prop. She introduced several non aggressive treatments that I am currently pursuing and I can attest that my knee is progressing well. Don’t live in pain call DR LARUSSO

    vitals-sprite2Anonymous Jan 23rd, 2016

    The Dr. Is attentive, caring, and very knowledgeable. Glad I found her.

    vitals-sprite2Joseph Marcianti Jan 20th, 2016

    My experience during my appt with dr Larusso was excellent. She was very professional. Has a good bed side manor and is willing to answer any question you may have. Overall it was a great experience.

    vitals-sprite2Mary Kate Connelly Jan 20th, 2016

    Dr. Larusso is an excellent diagnostician, a caring physician and an informative patient avocate. I would give six stars if I could

    vitals-sprite2Anonymous Jan 15th, 2016

    The doctor and staff are very nice and helpful, they explain details thoroughly. I would highly recommend them.

    vitals-sprite2Jacquelyn Danders Jan 13th, 2016

    Dr. Larusso made an uncomfortable procedure so pleasant. I was meeting her for the first time after a switch in my medical coverage and was in my feelings about that, her bedside manner was so professional, friendly and sincere, I immediately was at ease with my procedure and new doctor. She is a credit to the profession!!!

    vitals-sprite2Anonymous Jan 13th, 2016

    Dr. Larusso is the best , I would recommend her to everyone.

    vitals-sprite2Anonymous Jan 13th, 2016

    Excellent staff, wonderful doctor, minimal wait time.

    vitals-sprite2Anonymous Jan 11th, 2016

    I was suprised to see the professionalism and courtesy from an office and provider. She was nothing but helpful and took her time with me to understand my troubles.I must compliment on the staff as well as her medical assistants with their team like performance. Overall very impressed with my visit and will recommend to all.

    vitals-sprite2Denise Murach Jan 9th, 2016

    I highly recommend Dr. Larusso. She is very patient and caring. She takes time to explain everything, it’s very convenient that blood work is done at the office, I will definitely continue to see Dr. Larusso.

    vitals-sprite2Anonymous Jan 7th, 2016

    I highly recommend Dr. LaRusso!! She was able to accommodate my work schedule and I did not have to wait a long time for my appointment. As a new patient, Dr. LaRusso spent time reviewing my medical history and really listened to what I said. She was able to explain what was going on with my health and recommend a treatment plan that I want to follow. She explained things in a way that were clear and easy to follow. She provided me with a handout that discussed treatment options and actually asked me for my input. She asked me if I had any questions and when I couldn’t think of any, she shared a few common questions and provided the answers. In the past, when I have left a specialist’s office, I have felt overwhelmed and like I need to research my diagnosis and treatment options, but this was the first time I did not feel the need to go home and search online. I understand the goal of the treatment and when I need to follow up with Dr. LaRusso. An added perk was how nice and professional her office staff was during the visit and how efficient the process was from the time I entered the door until I left. The registration system was quick and preloaded with my information. Also, once I was in the exam room, I didn’t have to leave until I checked out. The phlebotomist came to the exam room to draw labs so I wouldn’t need to go to another room. I’m truly impressed with Dr. LaRusso and the efficiency of her medical practice.

    vitals-sprite2Aria Jan 5th, 2016

    She’s very caring. she goes above and beyond to make sure I’m in good health. She treats me like I’m family. I love her.

    vitals-sprite2Jodi Oct 26th, 2015

    I have been a patient of Dr. Melissa LaRusso for about two years or longer. I followed her from the last practice to this one. At this practice she is able to offer more choices of treatment.